indexice6

the aim of our systematic review and meta-analysis was to investigate whether overweight/obesity are associated with higher disease activity measures in axial spondyloarthritis (axSpA) patients. MEDLINE, PubMed and Web of Science were searched using key terms corresponding to population (axSpA), exposure (overweight/obesity) and outcome (Bath Ankylosing Spondylitis Disease Activity Index, BASDAI; Ankylosing spondylitis disease activity score, ASDAS). Predefined inclusion criteria were 1) adult axSpA patients 2) exposure classified according to Body Mass Index-BMI-; 3) BASDAI/ASDAS reported for each BMI group; 4) observational studies. Newcastle-Ottawa Scale for cohort, cross-sectional and case-control studies was used for quality check. Random-effects meta-analysis was used to pool results, which were expressed as mean difference (MD) in BASDAI and ASDAS between BMI groups, with 95% confidence intervals (95%CI). ten articles were included in the meta-analysis. The MD in BASDAI between normal BMI and oveSDAS.To better explain variation in language acquisition in children with hearing loss, this study examined vocal (e.g., vocalization) and lexical (e.g., word) imitation in spontaneous interactions between mothers and children with 12 months of hearing experience using their cochlear implants (n = 12; mean age 27.9 months). Hearing children in two control groups were matched to children with cochlear implants, either by child chronological age (n = 12; mean age = 27.4 months) or by child hearing experience (n = 12; mean age 12 months). All three groups of mother-child dyads were audio-recorded playing together. Mothers and children in all groups imitated their partners' vocalization and word utterances; however, the cochlear implant and hearing experience-matched groups produced fewer word imitations than the age-matched group. The frequency of preceding child vocalization or word production predicted maternal imitation type (vocalization or word); however, frequency of maternal vocalization predicted child vocalization imitation only. The results showed that child hearing experience affected imitation in both communication partners. To present epidemiological data on rheumatic heart disease (RHD), the most common acquired heart disease in children and young adults in low- and middle-income countries, for North-Central Nigeria. In this pilot study, we conducted clinical and echocardiography screening on a cross section of randomly selected secondary schoolchildren in Jos, North-Central Nigeria, from March to September 2016. For outcome classification into borderline or definite RHD, we performed a confirmatory echocardiography using the World Heart Federation criteria for those suspected to have RHD from the screening. A total of 417 secondary schoolchildren were screened, of whom 247 (59.2%) were female. The median age was 14years (IQR 13-15). Clinical screening detected 8/417 children, whereas screening echocardiography detected 42/417 suspected cases of RHD. Definitive echocardiography confirmed 9/417 with RHD corresponding to a prevalence of 21.6 per 1000 (95% CI, 6.7-36.5). All but one of the confirmed RHD cases (8/9) were borderline RHD corresponding to a prevalence of 19.2 per 1000 (95% CI, 8.3-37.5) for borderline RHD and 2.4 per 1000 (95% CI, 0.1-13.3) for definite RHD. RHD was more common in boys and cardiac auscultation missed over 50% of the cases. This study showed a high prevalence of RHD among secondary schoolchildren in North-Central Nigeria with a vast predominance of asymptomatic borderline lesions. Larger school-based echocardiography screening using portable or handheld echocardiography aimed at early detection of subclinical RHD should be adopted. This study showed a high prevalence of RHD among secondary schoolchildren in North-Central Nigeria with a vast predominance of asymptomatic borderline lesions. Larger school-based echocardiography screening using portable or handheld echocardiography aimed at early detection of subclinical RHD should be adopted.The vegetative phase change marks the beginning of the adult phase in the life cycle of plants and is associated with a gradual decline in the microRNA miR156, in response to sucrose status. Trehalose 6-phosphate (T6P) is a sugar molecule with signaling function reporting the current sucrose state. To elucidate the role of T6P signaling in vegetative phase change, molecular, genetic, and metabolic analyses were performed using Arabidopsis thaliana loss-of-function lines in TREHALOSE PHOSPHATE SYNTHASE1 (TPS1), a gene coding for an enzyme that catalyzes the production of T6P. These lines show a significant delay in vegetative phase change, under both short and long day conditions. Induced expression of TPS1 complements this delay in the TPS1 knockout mutant (tps1-2 GVGTPS1). Further analyses indicate that the T6P pathway promotes vegetative phase transition by suppressing miR156 expression and thereby modulating the levels of its target transcripts, the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE genes. Selleckchem BML-284 TPS1 knockdown plants, with a delayed vegetative phase change phenotype, accumulate significantly more sucrose than wild-type plants as a result of a feedback mechanism. In summary, we conclude that the T6P pathway forms an integral part of an endogenous mechanism that influences phase transitions dependent on the metabolic state.Aggregation of amyloid-β peptide 1-42 (Aβ42) initiates the onset of Alzheimer's disease (AD), and all the drugs designed to attenuate AD have failed in clinical trials. Emodin reduces levels of β-amyloid, tau aggregation, oxidative stress, and inflammatory response, demonstrating AD therapeutic potential, whereas its effect on the accumulation of the amyloid-β protein is not well understood. In this work, we investigated emodin activity on Aβ aggregation using a range of biochemical, biophysical, and cell-based approaches. We provide evidence to suggest that emodin blocks Aβ42 fibrillogenesis and Aβ-induced cytotoxicity, displaying a greater effect than that of curcumin. Through adopting three short peptides (Aβ1-16, Aβ17-33, and Aβ28-42), it was proven that emodin interacts with the Leu17-Gly33 sequence. Furthermore, our findings indicated that Val18 and Phe19 in Aβ42 are the target residues with which emodin interacts according amino acid mutation experiments. When fed to 8-month-old B6C3-Tg mice for 2 months, high-dose emodin ameliorates cognitive impairment by 60%-70%.